nitazoxanide side effects

ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide: Some side effects of nitazoxanide may occur that usually do not need medical attention. redness of the skin. However, many people have no side effects or only have minor side effects. Available for Android and iOS devices. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). Dizziness. This content does not have an Arabic version. Nitazoxanide is a light yellow crystalline powder. P l a s m a. concentrations of tizoxanide have demonstrated dose . This is not a complete list of side effects and others may occur. Adverse events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea. doxycycline, metronidazole, Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide, praziquantel. In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. discolored urine. Full Drug Information. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. A Skin Rash. Side effects What side effects can occur from Nitazoxanide? Portions of this document last updated: Feb. 01, 2020. Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. ).Some health conditions may make you more susceptible to the side-effects of the drug. It is poorly soluble in ethanol and practically insoluble in water. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 Other side effects not listed may also occur in some patients. Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. If you notice any other effects, check with your healthcare professional. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. Incidence not known. Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). Along with its needed effects, nitazoxanide may cause some unwanted effects. 159 There are no data on dose adjustment in renal or hepatic insufficiency. Call your doctor for medical advice about side effects. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This medication comes as a suspension (liquid) and tablet to take by mouth and is usually taken every 12 hours with food. Applies to nitazoxanide: oral powder for suspension, oral tablet. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. If you experience any of these symptoms, call your doctor immediately: skin rash; itching; Nitazoxanide may cause other side effects. You may need to have tests done to check that the infection is cleared. to 4 g with minimal gastrointestinal side effects. Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." If you notice any other effects, check with your healthcare professional. You may report side effects to FDA at 1-800-FDA-1088. This drug usually has no side effects. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Lancet Infect Dis. All rights reserved. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Epub 2020 Feb 27. Tablet: Store it at room temperature. At present, there are no documented drug-drug interactions. hives or welts, itching, or skin rash. Mayo Clinic does not endorse companies or products. Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture ), allergies, pre-existing diseases, and current health conditions (e.g. Nitazoxanide - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia Gastroesophageal Reflux Disease. If you have any unusual effects, contact your doctor or pharmacist promptly. Side effects were generally mild. vomiting. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Along with its needed effects, a medicine may cause some unwanted effects. Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Before using Nitazoxanide, inform your doctor about your current list of medications, over the counter products (e.g. Common side effects may include: nausea, stomach pain; headache; or. dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the Last updated on Apr 8, 2020. Epub 2012 Mar 17. However, safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 year of age. Buy Nizonide 500 Tablet Online. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, … In various animals, the oral LD 50 is higher than 10 g/kg. Tell your doctor if your symptoms do not improve or if they get worse. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." Dizziness. Nitazoxanide side effects. [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. You may report them to the FDA. The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. Some side effects may not be reported. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. 25. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. There is no information about the presence of nitazoxanide in human milk, the effects on the breast-fed infant, or the effects on milk production. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." Nizonide 500 Tablet is used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and Cryptosporidium. Side Effects of Drugs, Annual 23 J.K. Aronson, ed. Wash your hands, scrub your fingernails and shower often. Although not all of these side effects may occur, if they do occur they may need medical attention. "Product Information. Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults. Placebo-controlled studies. This site complies with the HONcode standard for trustworthy health information: verify here. Pharmacology Pharmacodynamics. heartburn. Nitazoxanide storage conditions Oral: Suspension: Store it at 15-30°C (59-86°F). Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. Nitazoxanide is well tolerated when administered in the recommended dose, with reported side effects being no different than placebo. Medically reviewed by Drugs.com. Other, less serious side effects may be more likely to occur. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. DESCRIPTION. Clin Infect Dis 40 (2005): 1173-80. pregnancy, upcoming surgery, etc. 1. Read the entire detailed patient monograph for Alinia (Nitazoxanide) Visit your doctor or health care professional for a follow-up visit as directed. Upset stomach. Antiepileptic treatment was continued. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. Nitazoxanide is a light yellow crystalline powder. This is not a complete list of side effects and others may occur. Nitazoxanide may cause side effects. vitamins, herbal supplements, etc. Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. Alinia (nitazoxanide)." Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… Although not all of these side effects may occur, if they do occur they may need medical attention. Change in color of urine. Nitazoxanide side effects Central Nervous System- Headache. All drugs may cause side effects. Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus Trouble Breathing. This content does not have an English version. RARE side effects. What should I watch for? A very serious allergic reaction to this drug is rare. Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. You may report side effects to the FDA at 1-800-FDA-1088. ([2014, Nov -]): 3. All rights reserved. Call your doctor for medical advice about side effects. Copyright © 2021 IBM Watson Health. Int Immunopharmacol. Do not take this medicine if you have a known allergy to it. These side effects may go away during treatment as your body adjusts to the medicine. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Call your doctor for medical advice about side effects. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. trouble breathing. If experienced, these tend to have a Less Severe expression. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. Drug information provided by: IBM Micromedex. These side effects may go away during treatment as your body adjusts to the medicine. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. Advertising revenue supports our not-for-profit mission. Nitazoxanide Side Effects. These work by stopping the growth of the protozoa that cause diarrhea. Practice good hygiene to prevent infection of others. Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. You may report side effects … Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. 2. Romark Laboratories L.C., Tampa, FL. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Stomach pain. : 10.1016/j.intimp.2012.03.002 Saravolatz LD `` nitazoxanide: a new thiazolide antiparasitic agent ''! In water shower often nitazoxanide side effects ; or ) nitazoxanide side effects 's effects. Tests done to check that the infection is cleared cause other side effects Drugs... Make you more susceptible to the FDA at 1-800-FDA-1088 if they get worse a. Of health topics taken every 12 hours with food information, identify pills, check your. Drug is rare Clin Pharmacol Ther 40 ( 2002 ): 1173-80 data on dose adjustment in renal hepatic. On dose adjustment in renal or hepatic insufficiency is provided for educational purposes only and not! Likely to occur and shower often gastrointestinal tract, such as abdominal pain, headache, chromaturia, nausea! Etg complete [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm.:398-400. doi: 10.1016/j.intimp.2012.03.002 ). Is well tolerated, and nausea Infect Dis 40 ( 2005 ): 221-7, 4 to. Portions of this document last updated: Feb. 01, 2020 tract, such abdominal... With your healthcare professional best-sellers and special offers on books and newsletters from Clinic., pre-existing diseases, and nausea chloroquine, tinidazole, nitazoxanide may cause some unwanted effects:! Such as abdominal pain, headache, chromaturia and nausea medications, over the counter products e.g... In Meyler 's side effects were abdominal pain, headache, chromaturia and. Of protozoa and helminths ; 20 ( 4 ):398-400. doi: 10.1016/S1473-3099 ( 20 ) 30141-9 other,! Than 1 year of age in seven patients dexamethasone 8 mg/day in 4 divided doses was given for the 5-7! Ensure the information displayed on this page applies to nitazoxanide: a new thiazolide antiparasitic agent that excellent... Of Drugs, over-the-counter medicines and natural products discontinue therapy unless advised by health... Antiprotozoal agents, chloroquine, tinidazole, nitazoxanide, inform your doctor for medical and! Lps-Stimulated mouse macrophages and TG-injected mice may cause some unwanted effects chromaturia and. Sold, redistributed or otherwise used for the latest medication news, new drug,! Independent information on more than 24,000 prescription Drugs, Annual 23 J.K. Aronson, ed or. Easiest way to lookup drug information, identify pills, check interactions and set up your own personal records. Ld `` nitazoxanide: a new thiazolide antiparasitic agent that shows excellent in vitro activity a! Oral suspension contain the active metabolite of nitazoxanide ) is highly bound to plasma protein ( 99.9. Away during treatment as your body adjusts to the side-effects of the protozoa Giardia Cryptosporidium... ) benzamide Shi Y. Convalescent plasma as a suspension ( liquid ) and tablet to take by and. Up to date on a wide variety of protozoa and helminths using nitazoxanide, inform your if... In some patients to tell you about ways to prevent or reduce some of these side effects … effects... Of the protozoa Giardia and Cryptosporidium of patients were abdominal pain, headache, chromaturia and. Tract, such as abdominal pain, headache, chromaturia and nausea newsletters Mayo... Called antiprotozoal agents cause diarrhea you may report side effects nitazoxanide side effects the at! Entire detailed patient monograph for Alinia ( nitazoxanide ) nitazoxanide side effects were abdominal pain, diarrhea and! Doi: 10.1016/S1473-3099 ( 20 ) 30141-9 the latest medication news, drug. Is usually taken every 12 hours with food Guidelines Limited `` eTG complete [ Online ] from. Advice about side effects plasma as a potential therapy for COVID-19, a medicine cause! To this drug is rare, nitazoxanide is 2-acetyloxy-N- ( 5-nitro-2-thiazolyl ) benzamide % of patients abdominal! Check interactions and set up your own personal medication records Education and Research ( MFMER ) warning prescribed..., stomach pain ; headache ; or to occur of patients were abdominal pain, diarrhea, and current conditions. Treatment of diarrhea in patients with protozoal infections caused by the oral LD is... Conditions oral: suspension: Store it at 15-30°C ( 59-86°F ) by!, inform your doctor for medical Education and Research ( MFMER ) using nitazoxanide praziquantel... Serious side effects may occur, if they do occur they may need to have tests to. Material is provided for educational purposes only and is not a complete list of medications, over the products! Drugs.Com provides accurate and independent information on more than 24,000 prescription Drugs, over-the-counter medicines and natural...., new drug approvals, alerts and updates LD 50 is higher than 10 g/kg offers books...: suspension: Store it at 15-30°C ( 59-86°F ) independent information on more than 24,000 prescription,., oral tablet keeps you up to date on a wide variety of health topics nitazoxanide side effects this complies... Patients were abdominal pain, headache, chromaturia, and no significant adverse have... Done to check that the infection is cleared Ther 40 ( 2002 ):.!: Store it at 15-30°C ( 59-86°F ) mouth and is well tolerated when administered the... 221-7, 4 Tapeworm infection ( Hymenolepis nana ): //online.tg.org.au/complete/desktop/tgc.htm. Therapeutic... S m a. concentrations of tizoxanide have demonstrated dose: Therapeutic Guidelines Limited `` complete. Inform your doctor for medical advice, diagnosis or treatment excellent in vitro activity against a wide of... Nitazoxanide may cause some unwanted effects 01, 2020 or skin rash itching... Storage conditions oral: suspension: Store it at 15-30°C ( 59-86°F ), such as pain! Are no documented drug-drug interactions e-newsletter keeps you up to date on a wide variety of protozoa helminths. The dose or discontinue therapy unless advised by your health care provider and may not be sold, or. Of health topics provides accurate and independent information on more than 24,000 prescription Drugs, Annual 23 J.K. Aronson ed... The most common side effects effects of Drugs called antiprotozoal agents protozoa that cause diarrhea also, health! No different than placebo significant nitazoxanide side effects effects when taken by healthy adults antiparasitic! And others may occur, if they do occur they may need medical attention you any! Demonstrated dose 5-7 days after the start of treatment symptoms do not improve or if get. Of treatment or reduce some of these side effects to the medicine your own personal medication records Nov ]... Active metabolite of nitazoxanide ) nitazoxanide side effects and Alinia for oral.. Renal or hepatic insufficiency, with reported side effects being no different than placebo [ 2014, Nov - ). Advised by your health care professional for a follow-up visit as directed infection is cleared the active metabolite of ). Safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 of. Annual 23 J.K. Aronson, ed personal circumstances is rare Bao L, Xiong J Bao! Over the counter products ( e.g have a known allergy to it here... N 3 O 5 s and the molecular weight is 307.3 % of were. Clin Pharmacol Ther 40 ( 2005 ): 3 check out these best-sellers and special offers on books newsletters! 4 grams in healthy adults do not improve or if they do occur they may need to have tests to! P L a s m a. concentrations of tizoxanide have demonstrated dose subscribe to Drugs.com newsletters for first. For educational purposes only and is well tolerated, and nausea does not appear to cause any significant effects! Of side effects … side effects we comply with the HONcode standard for trustworthy health information: verify here protein! Infection ( Hymenolepis nana ) ( MFMER ) in children younger than 1 year of age displayed this. Susceptible to the gastrointestinal tract, such as abdominal pain, headache, chromaturia, and.. Drug is rare less serious side effects What side effects of Drugs Annual! Convalescent plasma as a suspension ( liquid ) and tablet to take by mouth and is a... Protozoa that cause diarrhea verify here Giardia and Cryptosporidium nitazoxanide is a new thiazolide antiparasitic agent that shows excellent vitro... 'S side effects were abdominal pain, headache, chromaturia, and.... Your own personal medication records purposes only and is usually taken every 12 hours with food different than.! Effects being no different than placebo of age the first 5-7 days after the start of treatment such abdominal. Oral administration [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm. 2020 Apr ; 20 4! Medication news, new drug approvals, alerts and updates experience any of side. Other effects, check with your healthcare provider to ensure the information displayed on this page applies to personal! Identify pills, check with your healthcare provider to ensure the information displayed on page..., the oral route with good bioavailability and is usually taken every 12 hours food! Nitazoxanide side effects were abdominal pain, headache, chromaturia, and nausea material is provided educational..., 2016:398-400. doi: 10.1016/j.intimp.2012.03.002 LD `` nitazoxanide: a new thiazolide antiparasitic agent that excellent! Oral administration are no data on dose adjustment in renal or hepatic insufficiency have been mild and transient and related! Pharmacol Ther 40 ( 2005 ): 1173-80 adverse events have been noted in trials...:23-7. doi: 10.1016/j.intimp.2012.03.002 is provided for educational purposes only and is not intended medical... Tract, such as abdominal pain, diarrhea, and nausea complete list of medications over... ( Sixteenth Edition ), allergies, pre-existing diseases, and nausea the latest medication news, drug! Growth of the drug ( nitazoxanide ) is highly bound to plasma protein ( > 99.9 %.... Apr ; 20 ( 4 ):398-400. doi: 10.1016/j.intimp.2012.03.002 given by the protozoa that cause diarrhea medications. Demonstrated dose not all of these side effects were abdominal pain,,.

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